100 English films of 2006 ranked by box office. #1: Pirates of the Caribbean: Dead Man's Chest ($1.1 billion).
| # | Film | Lead | Director | Budget | Box office | Multiple |
|---|---|---|---|---|---|---|
| 1 | Pirates of the Caribbean: Dead Man's Chest | Gore Verbinski | $225 million | $1.1 billion | 4.74x | |
| 2 | The Da Vinci Code | Ron Howard | $125 million | $801.3 million | 6.41x | |
| 3 | Ice Age: The Meltdown | Carlos Saldanha | $80 million | $667 million | 8.34x | |
| 4 | Casino Royale | Martin Campbell | ARS 150 million | $606 million | ||
| 5 | Night at the Museum | Shawn Levy | $110 million | $574.5 million | 5.22x | |
| 6 | Cars | John Lasseter | $120 million | $471.5 million | 3.93x | |
| 7 | 300 | Zack Snyder | $65 million | $468.8 million | 7.21x | |
| 8 | X-Men: The Last Stand | Brett Ratner | $210 million | $460 million | 2.19x | |
| 9 | Superman Returns | Bryan Singer | $270 million | $391.1 million | 1.45x | |
| 10 | Happy Feet | George Miller | $100 million | $384.3 million | 3.84x | |
| 11 | Hammy's Boomerang Adventure | Will Finn | $80 million | $339.8 million | 4.25x | |
| 12 | The Devil Wears Prada | David Frankel | $35 million | $327 million | 9.34x | |
| 13 | The Pursuit of Happyness | Gabriele Muccino | $55 million | $307.1 million | 5.58x | |
| 14 | The Departed | Martin Scorsese | $90 million | $291.5 million | 3.24x | |
| 15 | Click | Frank Coraci | $85 million | $268.7 million | 3.16x | |
| 16 | Borat | Larry Charles | HK$18 million | $262.6 million | ||
| 17 | Eragon | Stefen Fangmeier | $100 million | $250.4 million | 2.50x | |
| 18 | The Holiday | Nancy Meyers | $85 million | $205.8 million | 2.42x | |
| 19 | The Break-Up | Peyton Reed | $52 million | $205.7 million | 3.96x | |
| 20 | Boog and Elliot's Midnight Bun Run | Anthony Stacchi | $85 million | $200.8 million | 2.36x | |
| 20 | Open Season | Roger Allers | $85 million | $200.8 million | 2.36x | |
| 22 | Inside Man | Spike Lee | $45 million | $184.4 million | 4.10x | |
| 23 | Poseidon | Wolfgang Petersen | $160 million | $181 million | 1.13x | |
| 24 | Déjà Vu | Tony Scott | $75 million | $180.6 million | 2.41x | |
| 25 | Scary Movie 4 | David Zucker | $40 million | $178.7 million | 4.47x | |
| 26 | Blood Diamond | Edward Zwick | $100 million | $171.7 million | 1.72x | |
| 27 | Saw III | Darren Lynn Bouseman | $10 million | $164.9 million | 16.49x | |
| 28 | Miami Vice | Michael Mann | $135 million | $164.2 million | 1.22x | |
| 29 | The Pink Panther | Shawn Levy | $80 million | $164.1 million | 2.05x | |
| 30 | World Trade Center | Oliver Stone | $63 million | $163.5 million | 2.60x | |
| 31 | Talladega Nights: The Ballad of Ricky Bobby | Adam McKay | $72.5 million | $163.4 million | 2.25x | |
| 32 | The Fast and the Furious: Tokyo Drift | Justin Lin | $85 million | $159 million | 1.87x | |
| 33 | Rocky Balboa | Sylvester Stallone | $24 million | $156 million | 6.50x | |
| 34 | Dreamgirls | Bill Condon | $75 million | $155.4 million | 2.07x | |
| 35 | Charlotte's Web | Gary Winick | $85 million | $148.9 million | 1.75x | |
| 36 | Garfield: A Tail of Two Kitties | Tim Hill | $60 million | $143.3 million | 2.39x | |
| 37 | Monster House | Gil Kenan | $75 million | $142 million | 1.89x | |
| 38 | Big Momma's House 2 | John Whitesell | $40 million | $141.5 million | 3.54x | |
| 39 | Babel | Alejandro González Iñárritu | $25 million | $135.3 million | 5.41x | |
| 40 | Perfume: The Story of a Murderer | Tom Tykwer | $60 million | $135 million | 2.25x | |
| 41 | You, Me and Dupree | Joe Russo | $54 million | $130.6 million | 2.42x | |
| 42 | Failure to Launch | Tom Dey | $50 million | $130.2 million | 2.60x | |
| 43 | The Queen | Stephen Frears | $15 million | $123.5 million | 8.23x | |
| 44 | Eight Below | Frank Marshall | $40 million | $120.5 million | 3.01x | |
| 45 | The Omen | John Moore | $25 million | $120 million | 4.80x | |
| 46 | Final Destination 3 | James Wong | $25 million | $118.9 million | 4.76x | |
| 47 | The Lake House | Alejandro Agresti | $40 million | $114.8 million | 2.87x | |
| 48 | Step Up | Anne Fletcher | $12 million | $114 million | 9.50x | |
| 49 | The Santa Clause 3: The Escape Clause | Michael Lembeck | $12 million | $110.8 million | 9.23x | |
| 50 | The Prestige | Christopher Nolan | $40 million | $109 million | 2.73x | |
| 51 | Arthur and the Minimoys | Luc Besson | €60 million | $107.9 million | ||
| 52 | Little Man | Keenen Ivory Wayans | $64 million | $105 million | 1.64x | |
| 53 | Little Miss Sunshine | Jonathan Dayton | $8 million | $101.1 million | 12.64x | |
| 54 | Silent Hill | Christophe Gans | $50 million | $100.6 million | 2.01x | |
| 55 | The Good Shepherd | Robert De Niro | $80 million | $100.3 million | 1.25x | |
| 56 | Nacho Libre | Jared Hess | $35 million | $99 million | 2.83x | |
| 57 | Deep Sea 3D | Howard Hall | $1 million | $96.9 million | 96.90x | |
| 58 | The Guardian | Andrew Davis | $70 million | $95 million | 1.36x | |
| 59 | The Illusionist | Neil Burger | $17 million | $87.8 million | 5.16x | |
| 60 | RV | Barry Sonnenfeld | $50 million | $87.5 million | 1.75x | |
| 61 | The Shaggy Dog | Brian Robbins | $50 million | $87.1 million | 1.74x | |
| 62 | Date Movie | Aaron Seltzer | $20 million | $84.8 million | 4.24x | |
| 63 | Jackass Number Two | Jeff Tremaine | $11.5 million | $84.6 million | 7.36x | |
| 64 | Firewall | Richard Loncraine | $50 million | $82.8 million | 1.66x | |
| 65 | The Sentinel | Clark Johnson | $60 million | $78.8 million | 1.31x | |
| 66 | United 93 | Paul Greengrass | $15 million | $77.6 million | 5.17x | |
| 67 | Lady in the Water | M. Night Shyamalan | $70 million | $72.8 million | 1.04x | |
| 68 | The Grudge 2 | Takashi Shimizu | $20 million | $70.7 million | 3.54x | |
| 69 | Children of Men | Alfonso Cuarón | $76 million | $70.5 million | 0.93x | |
| 69 | The Possibility of Hope | Alfonso Cuarón | $76 million | $70.5 million | 0.93x | |
| 71 | John Tucker Must Die | Betty Thomas | $18 million | $68.8 million | 3.82x | |
| 72 | Letters from Iwo Jima | Clint Eastwood | $19 million | $68.7 million | 3.62x | |
| 73 | When a Stranger Calls | Simon West | $15 million | $67.1 million | 4.47x | |
| 74 | Take the Lead | Liz Friedlander | $30 million | $66.2 million | 2.21x | |
| 75 | Flags of Our Fathers | Clint Eastwood | $90 million | $65.9 million | 0.73x | |
| 76 | 16 Blocks | Richard Donner | $52 million | $65.7 million | 1.26x | |
| 77 | The Secret | Drew Heriot | $3.5 million | $65.6 million | 18.74x | |
| 78 | The Benchwarmers | Dennis Dugan | $33 million | $65 million | 1.97x | |
| 79 | Madea's Family Reunion | Tyler Perry | $6 million | $63.4 million | 10.57x | |
| 80 | Snakes on a Plane | David R. Ellis | $33 million | $62 million | 1.88x | |
| 81 | My Super Ex-Girlfriend | Ivan Reitman | $30 million | $61.1 million | 2.04x | |
| 82 | Marie Antoinette | Sofia Coppola | $40 million | $60.9 million | 1.52x | |
| 83 | Invincible | Ericson Core | $30 million | $58.5 million | 1.95x | |
| 84 | Smokin' Aces | Joe Carnahan | $17 million | $57.3 million | 3.37x | |
| 85 | She's the Man | Andy Fickman | $20 million | $57.2 million | 2.86x | |
| 86 | Lucky Number Slevin | Paul McGuigan | $27 million | $56.3 million | 2.09x | |
| 87 | Stranger than Fiction | Marc Forster | $30 million | $53.7 million | 1.79x | |
| 88 | The Texas Chainsaw Massacre: The Beginning | Jonathan Liebesman | $13 million | $51.8 million | 3.98x | |
| 89 | Notes on a Scandal | Richard Eyre | $15 million | $50.6 million | 3.37x | |
| 90 | An Inconvenient Truth | Davis Guggenheim | $1 million | $49.8 million | 49.80x | |
| 91 | The New World | Terrence Malick | $30 million | $49.3 million | 1.64x | |
| 91 | The Black Dahlia | Brian De Palma | $50 million | $49.3 million | 0.99x | |
| 93 | The Last King of Scotland | Kevin Macdonald | $6 million | $48.4 million | 8.07x | |
| 94 | Deck the Halls | John Whitesell | $51 million | $47.2 million | 0.93x | |
| 95 | The Nativity Story | Catherine Hardwicke | $35 million | $46.4 million | 1.33x | |
| 96 | We Are Marshall | McG | $65 million | $43.5 million | 0.67x | |
| 97 | Last Holiday | Wayne Wang | $45 million | $43.3 million | 0.96x | |
| 98 | Crank | Brian Taylor | $12 million | $42.9 million | 3.58x | |
| 98 | Glory Road | James Gartner | $30 million | $42.9 million | 1.43x | |
| 100 | A Good Year | Ridley Scott | $35 million | $42.3 million | 1.21x |
Figures are shown in the currency they were reported in (Wikipedia, Wikidata or TMDB); no conversion.