22 Tamil films of 2022 ranked by box office. #1: Ponniyin Selvan: I (₹500 crore).
| # | Film | Lead | Director | Budget | Box office | Multiple |
|---|---|---|---|---|---|---|
| 1 | Ponniyin Selvan: I | Vikram | Mani Ratnam | $29.5 million | ₹500 crore | |
| 2 | Vikram | Vijay Sethupathi | Lokesh Kanagaraj | ₹120 crore | ₹424 crore | 3.53x |
| 3 | Beast | Vijay | Baltasar Kormákur | ₹130 crore | ₹216 crore | 1.66x |
| 4 | Valimai | Ajith Kumar | H. Vinoth | ₹150 crore | ₹163.2 crore | 1.09x |
| 5 | Don | Sivakartikeyan | ₹120 crore | |||
| 6 | Thiruchitrambalam | Dhanush | Mithran Jawahar | ₹115 crore | ||
| 7 | Love Today | Pradeep Ranganathan | Pradeep Ranganathan | ₹5 crore | ₹105 crore | 21.00x |
| 8 | Sardar | Karthik Siva kumar | P.S Mithran | ₹100 crore | ||
| 9 | Vendhu Thanindhathu Kaadu | Silambarasan | Gautham Vasudev Menon | ₹30 crore | ₹85 crore | 2.83x |
| 10 | Etharkkum Thunindhavan | Suriya | Pandiraj | ₹75 crore | ₹71.4 crore | 0.95x |
| 11 | Kaathuvaakula Rendu Kaadhal | Vijay Sethupathi | Vignesh Shivan | ₹70 crore | ||
| 12 | Yaanai | Arun Vijay | Hari | ₹15 crore | ₹65 crore | 4.33x |
| 13 | Viruman | Karthi | M. Muthaiah | ₹60 crore | ||
| 14 | Prince | Sivakartikeyan | K. V. Anudeep | ₹40 crore | ||
| 15 | Yashoda | Samantha Prabhu | Hareesh Narayan | ₹30 crore | ₹32 crore | 1.07x |
| 16 | Gatta Kusthi | Chella Ayyavu | ₹30 crore | |||
| 17 | Oke Oka Jeevitham | Sharwanand | Shree Karthick | ₹26.1 crore | ||
| 18 | FIR (2022 film) | Vishnu Vishal | Manu Anand | ₹24 crore | ||
| 19 | Connect | Ashwin Saravanan | ₹20 crore | |||
| 20 | Oh My Ghost | ₹10 crore | ₹14 crore | 1.40x | ||
| 21 | Gargi | Sai Pallavi | Gautham Ramachandran | ₹8.9 crore | ||
| 22 | Hey Sinamika | Dulquer Salmaan | Brinda | ₹15 crore | ₹5 crore | 0.33x |
Figures are shown in the currency they were reported in (Wikipedia, Wikidata or TMDB); no conversion.