| Director | Raja Gosnell |
|---|---|
| Budget | $110 million |
| Box office | $564 million |
In Smurf Village, the Smurfs are preparing for the Festival of the Blue Moon. Papa Smurf sees a vision of Clumsy Smurf reaching for a dragon wand and Gargamel capturing the Smurfs. Shortly after, Clumsy leaves to pick smurfroot and ends up leading Gargamel into the village. The Smurfs flee and Clumsy unknowingly runs toward the Forbidden Falls, with Papa, Smurfette, Grouchy, Brainy and Gutsy following him. The blue moon appears and creates a portal that spirits the Smurfs to New York City, and Gargamel and his pet cat Azrael follow them. Clumsy then falls into a box belonging to Anjelou Cosmetics employee Patrick Winslow, who unknowingly carries him to his apartment, where he lives with his pregnant wife Grace.
Papa, Smurfette, Brainy, Grouchy and Gutsy follow Clumsy, revealing themselves and explaining their situation to the Winslows, who give them shelter. The next day, needing to find a "stargazer", the Smurfs follow Patrick to his workplace at Anjelou, believing he is a fortune-teller. Meanwhile, Gargamel extracts Smurf essence from a lock of Smurfette's hair, which gives him magic powers. While searching for the Smurfs, he wanders into Anjelou and impresses Patrick's boss, Odile, by restoring her elderly mother's youth with his magic. Upon hearing of Patrick's connection to the Smurfs, Gargamel chases him and the Smurfs into FAO Schwarz, where he steals a leaf blower and causes chaos while trying to catch the Smurfs. He is arrested and jailed, but manages to escape with the aid of a swarm of flies.
Papa uses a toy telescope to calculate the night he and the others can return home, but needs to work out a spell first. The Smurfs visit an antique store to look for a spellbook and find L’Histoire des Schtroumpfs by researcher Peyo, which contains a spell that can turn the moon blue. Gargamel tracks them down in the store, where he finds the dragon wand from Papa's vision and transfers his magic into it to use it against the Smurfs. Papa entrusts the spell to Brainy and voluntarily stays behind to be captured by Gargamel.
After Clumsy convinces the others to rescue Papa, the Smurfs and Patrick travel to Belvedere Castle at Central Park, where Gargamel increases his wand's power with Papa's essence. Brainy successfully turns the moon blue and opens a portal to their world, from where he summons all the Smurfs of Smurf Village. While the Smurfs battle Gargamel, Smurfette and Patrick save Papa. Gutsy steals the dragon wand, but drops it in the process. Clumsy catches it and sends Gargamel flying away. The Smurfs bid Patrick and Grace farewell and return to Smurf Village.
Later, Patrick and Grace have a baby boy, whom they name Blue, and the Smurfs rebuild their village in the style of New York.