| Director | Tim Story |
|---|---|
| Genre | comedy film, family film, live-action/animated film, speculative fiction film |
| Runtime | 101 min |
| Country | United States |
| Budget | $50 million |
| Box office | $136 million |
A cat named Tom, who dreams of being a jazz pianist, moves to Manhattan and busks in Central Park, while a brown mouse named Jerry is in search of a new home. After Tom's piano is destroyed in an altercation, and Tom is exposed as a fraud and a regular cat playing the piano by the residents in Central Park all because of Jerry's antics, he chases Jerry, but accidentally tackles a young woman named Kayla Forester, causing her to lose her job. Down on her luck, Kayla wants to prove her talents and looks for a position at the city's fanciest hotel, the Royal Gate, where Jerry moves in and Tom fails to break in. Kayla, with a stolen resume, is hired to help plan a high-profile wedding and gets a tour of the hotel, while Jerry's usual antics involve stealing food and items to ramp up his new home, and Tom plans more strategies to enter the hotel and capture Jerry.
Local celebrities Preeta Mehta and her fiancé Ben are greeted, as they arrive, along with their pet bulldog Spike and cat Toots. All, except for Spike, are unaware of Jerry stealing from Preeta's handbag. As the couple and their pets are escorted to their room, Jerry's presence is revealed, which puts the wedding and the hotel at risk. Kayla offers to catch Jerry, but fails and realizes that he will be hard to catch. After many failed attempts, Tom successfully enters the hotel, and his ensuing chase after Jerry wrecks a hotel room. Due to noise complaints, Kayla comes to check and befriends Tom, due to their shared goal of catching Jerry. The hotel's owner and general manager Mr. Dubros hires Tom to exterminate Jerry, while Tom and Kayla's boss Terence threatens to fire them if Tom cannot catch Jerry.
After more failed attempts, Tom designs an elaborate mouse trap that gets Jerry out of the hotel. Meanwhile, Kayla helps with the wedding plans and learns that Preeta's engagement ring is missing. Jerry returns, to clash with Tom on the piano, and reveals to Kayla that he had Preeta's ring and agrees to give it back to her in exchange for letting him live in the hotel. Before Kayla can agree, Terence returns from walking Spike and notices Tom looking for Jerry hiding in Kayla's coat pocket, creating a scene that causes Spike, Tom, and Jerry's chase to destroy the lobby. Terence is suspended, while Kayla is promoted to event manager, for returning Preeta's ring. Kayla tells Tom and Jerry that they will have to get along and spend the next day bonding if they want to stay in the hotel, to which they reluctantly agree.
While Kayla takes care of the hotel and manages the wedding with the crew, Tom and Jerry explore the city, but are imprisoned at a pound, after inadvertently committing fan interference at a baseball game. A vengeful Terence separately visits Tom and Jerry and feeds them lies about what they said about each other behind their backs, leading to another duel at the ceremony that throws the wedding into chaos and destroys the rest of the hotel. After Kayla comes clean and leaves in disgrace, Terence evicts Tom, and Preeta renounces the wedding. Realizing that it is their fault, Tom and Jerry put their differences aside, and convince Kayla and the hotel crew, including a skeptical Terence, to salvage the wedding. The pair lure Preeta and Toots to Central Park, where the wedding is held.
Kayla promises to Preeta that Tom and Jerry have atoned for their behavior, and Ben apologizes to Preeta for his extensive expenses, in light of impressing her father. Kayla and the stolen resume's owner reconcile with each other and get jobs at the hotel, while Tom finally becomes a jazz pianist and plays the piano for Toots, with Jerry joining the party until a mishap causes them to fight again. In a post-credit scene, Ben receives a bill for both weddings.