| Director | S. J. Clarkson, S.J. Clarkson |
|---|---|
| Budget | $100 million |
| Box office | $100.5 million |
In 1973, a research team in the Amazon rainforest in Peru led by a pregnant Constance Webb discovers an unidentified spider species with rare healing properties. Ezekiel Sims, the man Constance hired for protection and security, betrays the team and claims the spider for himself, shooting Constance in a struggle and leaving her to die before fleeing with the spider. An indigenous tribe attempts to save Constance by having one of the spiders bite her. However, she dies shortly after giving birth to her daughter, Cassandra.
30 years later, Cassandra, who goes by "Cassie", works as a paramedic in New York City alongside her co-workers Ben Parker and O'Neil. During a dangerous call, she falls into the water and has a near-death experience. Ben revives Cassie, but she begins to experience visions. Initially, she dismisses them as déjà vu, but after failing to prevent O'Neil's death, she realizes she can see into the future. Ezekiel, who has limited precognition power and enhanced physical abilities, collects information on three teenage girls: Julia Cornwall, Anya Corazón, and Mattie Franklin. His visions lead him to believe that they are destined to kill him. Cassie is also drawn to the girls and intervenes to stop Ezekiel from ambushing them at Grand Central Terminal. She steals a taxi and takes the girls out of the city to hide them in a nearby forest.
Cassie returns to her apartment and finds her mother's notes, which tell of Ezekiel's identity and the true nature of his powers. Ignoring Cassie's instructions, the girls go to a diner where he finds them. After briefly incapacitating Ezekiel by ramming him with the taxi, Cassie takes the girls back to Queens, and they take refuge at Ben's. Cassie flies to Peru and tracks down Santiago, the tribal chief who had tried to save her mother. He puts her through a ritual that separates her soul from her body. She experiences a higher plane of consciousness in which all living things are connected, and every possible future can be seen. Cassie learns that her mother sought the spider not for fame or money, as she had initially believed, but to save Cassie from being born with myasthenia gravis, which the bite wound up curing. Santiago tells Cassie that accepting her responsibility can unlock her true power. Ben's pregnant sister-in-law Mary goes into labor earlier than expected, so he takes her to the hospital with the girls, who are seen on camera in the car. Ezekiel intercepts them again, but Cassie rescues the girls in an ambulance and distracts him long enough for Ben and Mary to get to the hospital.
The group lures Ezekiel to a condemned fireworks factory and sets up traps to disorient him while Cassie calls for a medical evacuation helicopter to fly to their location. He destroys it and separates the girls, then taunts her with Constance's death. Cassie uses her powers to guide the girls to safety, then lures Ezekiel into the final trap, which fatally crushes him. An ignited firework strikes Cassie in the face, severely injuring her. The girls save her, and she is taken to the hospital just as Mary gives birth to her son. Cassie wakes up to discover that she is now blind and paraplegic due to her injuries. However, her clairvoyance enables her to see the future more clearly. She assures the girls that she will mentor them in their future roles when the time comes.