Johnny Depp and Penélope Cruz have appeared together in 4 films between 1999 and 2017, with a combined box office of $1.5 billion. Every shared film with year, roles and gross, plus who else each works with most.
| Year | Film | Box office |
|---|---|---|
| 1999 | Pirates 4-D | |
| 2001 | Blow | $83.3 million |
| 2011 | Pirates of the Caribbean: On Stranger Tides | $1 billion |
| 2017 | Murder on the Orient Express | $353 million |
Johnny Depp also often with: Tim Burton (7), Christopher Lee (5), Geoffrey Rush (5), Helena Bonham Carter (5), Judi Dench (5)
Penélope Cruz also often with: Javier Bardem (4), Judi Dench (4), Ariadna Gil (3), Bronson Webb (3), Charlize Theron (3)