Santhanam and Mayilsamy have appeared together in 24 films between 1983 and 2023, with a combined box office of ₹153 crore. Every shared film with year, roles and gross, plus who else each works with most.
| Year | Film | Box office |
|---|---|---|
| 1983 | Mappilai Vinayagar | |
| 1986 | மச்சக்காரன் | |
| 2005 | February 14 | |
| 2005 | Sachein | ₹10 crore |
| 2006 | Rendu | |
| 2007 | Machakaaran | |
| 2007 | Thottal Poo Malarum | |
| 2008 | Kuselan | ₹8 crore |
| 2008 | Silambattam | |
| 2008 | Vaitheeswaran | |
| 2009 | Modhi Vilayadu | |
| 2009 | Thoranai | |
| 2010 | Theeradha Vilaiyattu Pillai | |
| 2010 | Thillalangadi | $10 million |
| 2011 | Osthe | |
| 2011 | Siruthai | ₹30 crore |
| 2011 | Yuvan Yuvathi | ₹10 crore |
| 2013 | Pattathu Yaanai | |
| 2014 | Idhu Kathirvelan Kadhal | |
| 2014 | Inga Enna Solluthu | |
| 2014 | Veeram | ₹83 crore |
| 2016 | Dhilluku Dhuddu | ₹12 crore |
| 2021 | Sabhaapathy | |
| 2023 | 80s Buildup |
Santhanam also often with: Manobala (34), Nassar (20), M. S. Bhaskar (18), Prakash Raj (18), Rajendran (18)
Mayilsamy also often with: Manobala (43), Vivek (30), Madhan Bob (25), Nassar (24), Ilavarasu (23)